New Evidence on Dengue and Zika Population Immunity from Sri Lanka

We are pleased to share a new publication in 𝗢𝗽𝗲𝗻 𝗙𝗼𝗿𝘂𝗺 𝗜𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝘂𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲𝘀 arising from the broader AEGIS programme conducted in Sri Lanka:
“𝘋𝘪𝘴𝘴𝘦𝘤𝘵𝘪𝘯𝘨 𝘢𝘨𝘦-𝘴𝘵𝘳𝘢𝘵𝘪𝘧𝘪𝘦𝘥 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺 𝘵𝘰 𝘥𝘪𝘧𝘧𝘦𝘳𝘦𝘯𝘵 𝘥𝘦𝘯𝘨𝘶𝘦 𝘷𝘪𝘳𝘶𝘴 𝘴𝘦𝘳𝘰𝘵𝘺𝘱𝘦𝘴 𝘢𝘯𝘥 𝘡𝘪𝘬𝘢 𝘷𝘪𝘳𝘶𝘴𝘦𝘴 𝘢𝘮𝘰𝘯𝘨 𝘤𝘩𝘪𝘭𝘥𝘳𝘦𝘯 𝘪𝘯 𝘢 𝘩𝘪𝘨𝘩𝘭𝘺 𝘦𝘯𝘥𝘦𝘮𝘪𝘤 𝘳𝘦𝘨𝘪𝘰𝘯 𝘪𝘯 𝘚𝘳𝘪 𝘓𝘢𝘯𝘬𝘢.”

This study was successfully managed by RemediumOne in Sri Lanka.,

This study assessed dengue and Zika virus seroprevalence among 4,161 children aged 4–16 years in a highly endemic region of Sri Lanka. The findings showed that 𝟳𝟮.𝟯% 𝗼𝗳 𝗰𝗵𝗶𝗹𝗱𝗿𝗲𝗻 were already 𝘀𝗲𝗿𝗼𝗽𝗼𝘀𝗶𝘁𝗶𝘃𝗲 𝗳𝗼𝗿 𝗱𝗲𝗻𝗴𝘂𝗲, with exposure increasing steadily with age.

The study further explored exposure to different dengue virus serotypes and Zika virus, providing important insights into population immunity and transmission dynamics in endemic settings.

Interestingly, a substantial proportion of children showed evidence of monotypic dengue infection, while others demonstrated exposure to multiple serotypes, highlighting the complex transmission dynamics within the region.

Using multiplex serology, the study also identified Zika virus exposure in 16.5% of participants, with an inverse relationship observed with age, raising important questions about the potential influence of prior dengue immunity on susceptibility to Zika virus infection.

These findings contribute valuable evidence to support dengue vaccine implementation strategies, vector control planning, and preparedness for future Aedes-borne viral outbreaks.

Access the paper: https://lnkd.in/gSEbTGa4